A tornado roared into southeast Alabama and killed at least 22 people and injured several others Sunday, part of a severe storm system that caused catastrophic damage and unleashed other tornadoes around the Southeast.

"We are at 22 right now. Unfortunately, I feel like that number may rise yet again," Lee County Sheriff Jay Jones said of the death toll.

Drones flying overheard equipped with heat-seeking devices had scanned the area for survivors but the dangerous conditions halted the search late Sunday, Jones said. An intense ground search would resume Monday morning.

Jones said the twister traveled straight down a key local artery in Beauregard and that the path of damage and destruction appeared at least a half mile wide. He said single-family homes and mobile homes were destroyed, adding some homes were reduced to slabs. He had told reporters earlier that several people were taken to hospitals, some with "very serious injuries."

Lee County Coroner Bill Harris told The Associated Press that he had to call in help from the state, because there were more bodies than his four-person office can handle.

The National Weather Service confirmed late Sunday a tornado with at least an F3 rating and a track at least half a mile (.8 kilometers) wide caused the deadly destruction in Alabama.

Dozens of emergency responders rushed to join search and rescue efforts in hard-hit Lee County after what forecasters said they think was a large tornado touched down Sunday afternoon, unleashed by a powerful storm system that also slashed its way across parts of Georgia, South Carolina and Florida.

Radar and video evidence showed what looked like a large tornado crossing the area near Beauregard shortly after 2 p.m. Sunday, said meteorologist Meredith Wyatt with the Birmingham office of the National Weather Service.